WebJan 1, 2024 · The full-length molecular weight of CENPF is 367 KDa and contains 3,210 amino acids [ 8 ]. In prostate cancer, CENPF has been shown to predict survival and tumor metastasis [ 9 ]. CENPF is directly associated with disease outcomes after undergoing gene amplification [ 10 ]. WebMar 20, 2024 · Among CENP family genes, CENPF and CENPE are mutated at high frequencies in various tumors, while CENPM and CENPA are less frequently mutated. Furthermore, CENPs regulate the tumor mutational burden, stemness, and microsatellite instability, and are associated with tumor immunity.
Centromere protein F promotes progression of …
WebFeb 28, 2024 · It is critical to develop new effective clinical biomarkers and drug targets in RCC. Several studies have shown that centromere protein F (CENPF), a microtubule binding protein, promotes cancer progression in various types of cancer. The purpose of this study was to explore the role of CENPF in RCC. WebCENPF(KO) cells had reduced global bio-energetic capacity, acetyl-CoA production, histone acetylation, and lipid metabolism, suggesting that CENPF is a critical regulator of cancer … the dream the bed frida kahlo
Frontiers A Novel Prognostic Signature for Survival Prediction and ...
WebJul 9, 2024 · CENPF protein has a broad expression in multiple tissues, such as the testis, bone marrow and lymph node . CENPF is also highly expressed in several types of human tumors, such as breast cancer, pancreatic carcinoma and prostate cancer and has been identified as a protein marker for tumor cell proliferation (9,10). To the best of our … WebNomogram indicated CENPF clinical predictive value for 1-, 3-, 5-, and 7-year melanoma overall survival. Therefore, CENPF plays a vital role in the progression and … WebOct 6, 2024 · Cervical cancer (CC) is the fourth most common female malignancy worldwide. More than half a million women are diagnosed with cervical cancer and the … the dream team logo