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Cenpf cancer

WebJan 1, 2024 · The full-length molecular weight of CENPF is 367 KDa and contains 3,210 amino acids [ 8 ]. In prostate cancer, CENPF has been shown to predict survival and tumor metastasis [ 9 ]. CENPF is directly associated with disease outcomes after undergoing gene amplification [ 10 ]. WebMar 20, 2024 · Among CENP family genes, CENPF and CENPE are mutated at high frequencies in various tumors, while CENPM and CENPA are less frequently mutated. Furthermore, CENPs regulate the tumor mutational burden, stemness, and microsatellite instability, and are associated with tumor immunity.

Centromere protein F promotes progression of …

WebFeb 28, 2024 · It is critical to develop new effective clinical biomarkers and drug targets in RCC. Several studies have shown that centromere protein F (CENPF), a microtubule binding protein, promotes cancer progression in various types of cancer. The purpose of this study was to explore the role of CENPF in RCC. WebCENPF(KO) cells had reduced global bio-energetic capacity, acetyl-CoA production, histone acetylation, and lipid metabolism, suggesting that CENPF is a critical regulator of cancer … the dream the bed frida kahlo https://harringtonconsultinggroup.com

Frontiers A Novel Prognostic Signature for Survival Prediction and ...

WebJul 9, 2024 · CENPF protein has a broad expression in multiple tissues, such as the testis, bone marrow and lymph node . CENPF is also highly expressed in several types of human tumors, such as breast cancer, pancreatic carcinoma and prostate cancer and has been identified as a protein marker for tumor cell proliferation (9,10). To the best of our … WebNomogram indicated CENPF clinical predictive value for 1-, 3-, 5-, and 7-year melanoma overall survival. Therefore, CENPF plays a vital role in the progression and … WebOct 6, 2024 · Cervical cancer (CC) is the fourth most common female malignancy worldwide. More than half a million women are diagnosed with cervical cancer and the … the dream team logo

Knockdown of CENPF inhibits the progression of lung …

Category:CENPF centromere protein F - NIH Genetic Testing …

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Cenpf cancer

CENPF promotes the proliferation of renal cell carcinoma

WebJan 24, 2024 · Based on these genes, we constructed and validated a 5-gene prognostic signature (including ACADM, CENPF, KDELC1, PLOD2, and TRMT1) to distinguish low- and high-risk KIRC patients of poor survival in TCGA and E-MTAB-1980 cohorts. WebCentromere protein F is a protein that in humans is encoded by the CENPF gene. [5] [6] [7] It is involved in chromosome segregation during cell division. It also has a role in the orientation of microtubules to form cellular cilia. [8] [9] Function [ edit]

Cenpf cancer

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WebExpression of CENPF (hcp-1) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... To access cancer specific RNA and … WebHepatocellular carcinoma (HCC) is one of the deadliest cancer types worldwide. The centromere proteins (CENPs) are critical for the mitosis-related protein complex and are …

WebOct 11, 2024 · The role of CENPF in breast cancer (BC) bone metastasis remains unclear. Methods Using the ONCOMINE database, we compared the expression of CENPF in breast cancer and normal tissues. Findings were confirmed in 60 BC patients through immunohistochemical (IHC) staining. WebFeb 21, 2024 · As confirmed by the Tumor Immune Estimation Resource, we found highly expressed centromere protein F (CENPF) in SKCM and its metastases. Immunostaining of human melanoma tissues demonstrated high CENPF expression.

WebJan 31, 2024 · CENPF has been found to be overexpressed in various malignant tumours, such as prostate cancer, breast cancer, and nasopharyngeal carcinoma, and to activate …

WebJan 1, 2024 · CENPF is identified upregulation in pancreatic cancer by genomics profile. • High expression of CENPF is correlated with poor prognosis of patients. • Silencing CENPF significantly inhibited PC cell proliferation, migration and EMT. • Silencing CENPF caused cell cycle arrest and tumorigenicity of pancreatic cells.

WebProduct name Anti-CENPF antibody See all CENPF primary antibodies Description Rabbit polyclonal to CENPF Host species Rabbit Tested applications Suitable for: IHC-P more details Species reactivity Reacts with: Human Predicted to work with: Chimpanzee, Gorilla, Orangutan Immunogen Synthetic peptide: the dream the maskWebMay 12, 2014 · The two genes— FOXM1 and CENPF —had been previously implicated in cancer, but none of the prior studies suggested that they might work synergistically to cause the most aggressive form of prostate cancer. The study was published today in the online issue of Cancer Cell. the dream tiWebMar 21, 2024 · The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or … the dream terius nashWebCentromere protein F is a protein that in humans is encoded by the CENPF gene. [5] [6] [7] It is involved in chromosome segregation during cell division. It also has a role in the … the dream team starring michael keatonWebApr 10, 2024 · In particular, CENPF overexpression is significantly associated with tumor metastasis and poor prognosis of hepatocellular carcinoma or breast cancer patients … the dream timersWebFeb 28, 2024 · • CENPF is a potential oncogene and prognostic marker in RCC, which can be used as an independent prognostic factor. Introduction Other Section Renal cell carcinoma (RCC) is the ninth most common cancer worldwide. It is estimated that there were more than 337,000 new cases diagnosed in 2012. the dream team giftsWebMar 3, 2024 · As one of the biomarkers for CAFs, CENPF can promote the proliferation ability of prostate cancer cells. The overexpress of CENPF could promote the proliferation ability of prostate cancer cells. In conclusion, we discuss the potential prognostic and therapeutic value of CAF-dependent pathways in prostate cancer. Introduction the dream tour dates