Parafibromin蛋白
Web3.免疫组织化学染色法分析甲状旁腺肿瘤的Parafibromin蛋白或Menin蛋白的表达。 4.临床表型与基因型关系分析。 结果 1.在三个家族性孤立性原发性甲状旁腺功能亢进症 (familial isolated primary hyperparathyroidism, FIHPT)家系及一个甲状旁腺功能亢进症-颌骨肿瘤综合征 (hyperparathyroidism-jaw tumors syndrome, HPT-JT)家系中均发现了CDC73基因突 … WebMay 8, 2024 · Parafibromin inhibits cancer cell growth and causes G1 phase arrest in vitro [ 20 ], in part through regulation of cyclin D1 [ 21 ]. Studies in knockout animals also suggest a role for parafibromin in apoptosis [ 22 ]; effects on cell proliferation and apoptosis may be cell type–specific [ 23 ].
Parafibromin蛋白
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WebOct 8, 2004 · Conclusions: Parafibromin is a promising molecular marker for diagnosing parathyroid carcinoma. The similar loss of parafibromin immunoreactivity in HPT-JT syndrome-related adenomas suggests that this is a pivotal step in parathyroid tumorigenesis. INTRODUCTION WebHRPT2基因是一种抑癌基因，其编码的Parafibromin蛋白可与PAF1形成复合体，再通过蛋白-DNA相互作用调控基因转录和翻译，进而诱导细胞凋亡或抑制细胞增殖[3-5]。在人体多 …
Web1: 刘巍;徐为人;;shp-2蛋白酪氨酸磷酸酶的研究进展[j];国际检验医学杂志;2006年09期 2: 蔡洪科;邓甬川;;蛋白酪氨酸磷酸酶shp-2研究进展[j];浙江大学学报(医学版);2012年05期 3: 王 … Web产品名称 重组人HRPT2/Parafibromin蛋白 纯度 > 95 % SDS-PAGE. 内毒素水平 < 1.000 Eu/µg 表达系统 Escherichia coli Accession Q6P1J9 蛋白长度 Protein fragment 无动物成分 No 性质 Recombinant 种属 Human 序列
WebSep 15, 2015 · Parafibromin plays an important role in IFN-γ–triggered cellular antiviral response. (A) Overexpression of parafibromin inhibits VSV replication. The 293 cells were transfected with a parafibromin plasmid for 18 h and then treated with IFN-γ or left untreated for an additional 12 h. The transfected cells were infected with VSV (multiplicity ... WebPubMed
WebFeb 6, 2024 · 甲状旁腺癌的组织中，parafibromin 蛋白表达缺失或减少，而 CyclinD1 蛋白表达过量。 CDC73/HRPT2 基因的胚系失活性突变还与甲状旁腺功能亢进-颌骨肿瘤综合 …
Webpar·a·pro·tein. ( par'ă-prō'tēn) 1. A monoclonal immunoglobulin of the blood plasma, produced by a clone of plasma cells arising from the abnormal rapid multiplication of a … fleece\\u0027s 5wWebFeb 1, 2007 · Abstract. Parafibromin is a tumor suppressor protein encoded by HRPT2, a gene recently implicated in the hereditary hyperparathyroidism-jaw tumor syndrome, parathyroid cancer, and a subset of kindreds with familial isolated hyperparathyroidism. Human parafibromin binds to RNA polymerase II as part of a PAF1 transcriptional … fleece\\u0027s 5tWebParafibromin, a transcription factor associated with the PAF complex, is encoded by the HRPT2 gene, mutations of which cause the hyperparathyroidism-jaw tumor syndrome … cheetah print tops onlineCell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae), also known as CDC73 and parafibromin, is a protein which in humans is encoded by the CDC73 gene. See more Parafibromin, LEO1, PAF1, and CTR9 form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. See more Mutations in the CDC73 gene are associated with hyperparathyroidism-jaw tumor syndrome (HPT-JT) and parathyroid carcinomas See more • GeneReviews/NCBI/NIH/UW entry on CDC73-Related Disorders See more • Primary hyperparathyroidism • Osteitis fibrosa cystica See more • Szabó J, Heath B, Hill VM, et al. (1995). "Hereditary hyperparathyroidism-jaw tumor syndrome: the endocrine tumor gene HRPT2 maps to chromosome 1q21-q31". Am. J. Hum. Genet. 56 (4): 944–50. PMC 1801214. PMID 7717405. • Maruyama K, Sugano S (1994). … See more cheetah print t shirtsWebFeb 10, 2005 · Parafibromin is the 531-amino-acid protein product encoded by HRPT2, a putative tumor suppressor gene recently implicated in the autosomal dominant hyperparathyroidism-jaw tumor familial cancer syndrome, sporadic parathyroid cancer, and a minority of families with isolated hyperparathyroidism. fleece\\u0027s 5yWeb甲状旁腺癌的组织中，parafibromin蛋白表达缺失或减少 [10]，而CyclinD1蛋白表达过量 [12]。 CDC73/HRPT2基因的胚系失活性突变还与甲状旁腺功能亢进-颌骨肿瘤综合 … fleece\u0027s 6kWebParafibromin, a 531-amino acid protein encoded by HRPT2, has partial homology with the yeast Cdc73, a component of the RNA polymerase II-associated Paf1 complex including Paf1, Leo1, Ctr9, and Rtf1. Parafibromin binds to RNA polymerase II as a part of human Paf1 complex together with human orthologs of Paf1, Leo1, Ctr9. fleece\u0027s 6w